The Wickersham Building at 170 Petaluma Boulevard North has a history as rich and varied as the cuisine at Graziano's. The building (featuring 20-inch-thick brick walls) was constructed in the 1850s by the attorney, banker, and cattleman Issac Wickersham. Mr. Wickersham built the first bank in Petaluma and was a member of the group that constructed the building which is now a part of the Great Petaluma Mill shopping complex.

The Wickersham Building was originally used for feed storage and was an integral part of Petaluma's thriving nineteenth-century river trade. The building has also housed Petaluma's first telephone exchange, a furniture store, a dentist, a beauty salon, a Chinese restaurant, and a silent movie theatre. In 1917 a fire gutted the 13,000-square-foot building but was quickly rebuilt and became home for Ben Franklin's Five-and-Dime and J.C. Penny's. It's been rumored that a speakeasy thrived in the building during Prohibition and at various times a red light burned in an upstairs window.